Differential Neuroendocrine Expression of Multiple Brain-Derived Neurotrophic Factor Transcripts
نویسندگان
چکیده
منابع مشابه
Differential neuroendocrine expression of multiple brain-derived neurotrophic factor transcripts.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin with important growth-promoting properties. We report here the first characterization of a BDNF gene in an amphibian, Xenopus laevis, and demonstrate that environmental factors can activate this gene in a promoter-specific fashion. The Xenopus BDNF gene contains six promoter-specific 5'-exons and one 3'-protein-encoding exon. We examine...
متن کاملDifferential Effects of Resveratrol on the Expression of Brain-Derived Neurotrophic Factor Transcripts and Protein in the Hippocampus of Rat Brain
Background: The induction of brain-derived neurotrophic factor (BDNF) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (RSV) on the learning and memory. The BDNF gene has a complicated structure with eight 5’ noncoding exons (I-IXa), each of which can splice to a common coding exon (IX) to form a functional transcript. Estrogens increase levels of ...
متن کاملDifferential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain.
Antidepressants are known to increase brain derived neurotrophic factor (BDNF) mRNA in the adult rat brain. The BDNF gene has four differentially regulated promoters that generate four transcript forms, each containing a unique non-coding 5' exon (exon I-IV) and a common 3' coding exon. Using in situ hybridization with exon-specific riboprobes, we have examined whether diverse classes of antide...
متن کاملdifferential effects of resveratrol on the expression of brain-derived neurotrophic factor transcripts and protein in the hippocampus of rat brain
background: the induction of brain-derived neurotrophic factor (bdnf) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (rsv) on the learning and memory. the bdnf gene has a complicated structure with eight 5’ noncoding exons (i-ixa), each of which can splice to a common coding exon (ix) to form a functional transcript. estrogens increase levels of ...
متن کاملThe Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats
Objective(s) The aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (STZ)-induced diabetic rat. Materials and Methods A total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). Diabetes was induced by injection of single dose of STZ. Exercise ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2008
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2008-0993